Bone pain on both sides of the mouth may be caused by jaw joint disorder syndrome, mandibular arthritis, and temporomandibular joint lesions. 1. Jaw Joint Disorder Syndrome: It may be related to sudden opening of the mouth and trauma. It is characterized by pain around the temporomandibular joint, abnormal sound of the temporomandibular joint, and abnormal movement of the jaw. Ibuprofen, acetaminophen and other drugs can be used as prescribed by the doctor. 2. Mandibular arthritis: clinical manifestations include localized soreness or pain, popping and movement disorders. Oral analgesic NSAIDs such as ibuprofen and celecoxib can be taken under doctor’s supervision to improve the symptoms. 3. Temporomandibular joint lesions: may manifest as pain in masticatory muscles, joint popping, difficulty in opening the mouth, headache and other symptoms. You can use diclofenac, indomethacin and other drugs under the guidance of the doctor to treat the symptoms. There are many causes of bone pain on both sides of the mouth, and it is recommended that patients seek timely medical attention when they experience discomfort.