Nails with vertical lines and depressions may be caused by ringworm of the nails, lack of trace elements, nail psoriasis and other causes, after clarifying the causes, you can be treated by using antifungal drugs, vitamin supplements, treatment of the original disease and other ways. 1. Onychomycosis: Nails with vertical lines, depression, if accompanied by thickening of the nails, cracking, consider onychomycosis. Itraconazole capsules can be taken orally. Adverse reactions include cardiac arrest, abnormal liver function, and allergy. Allergic to this product is prohibited. 2. Trace element deficiency: Nail vertical lines and depression caused by trace element deficiency can be supplemented with vitamins. 3. Nail psoriasis: psoriasis can also cause nail indentation, which is called “thimble phenomenon”, but at the same time, it is also accompanied by skin erythema, papules, scales and other manifestations. The treatment of psoriasis should be the main focus for nail changes caused by this disease. If there is any discomfort, please consult a doctor in a timely manner, and medication should be applied reasonably according to the doctor’s instructions.