Urticaria caused by sleep deprivation should firstly be treated with urticaria, such as oral medication loratadine, etc. Secondly, sleep deprivation should be regulated and treated, such as oral sleep aids such as benzodiazepines. For urticaria, the clinical treatment is generally to avoid contact with allergens, improve immunity, and at the same time can apply drugs: such as loratadine, paracetamol, dexamethasone acetate cream, glycerite lotion, etc. for treatment. Secondly, hives caused by sleep deprivation, need to regulate the symptoms of sleep deprivation, treatment, such as can be under the guidance of the doctor to take some drugs to help sleep such as benzodiazepines. You can also adjust the sleep environment, such as maintaining a quiet sleep environment. Clinical medication has great individual differences, the specific medication needs to be under the guidance of the doctor. It is recommended that patients should develop good living habits and ensure sufficient sleep. Avoid contact with allergens and spicy foods. Moderate consumption of fresh vegetables and fruits to supplement vitamins. If there is any other discomfort, go to the hospital in time.