Wearing rubber gloves with small blisters is generally contact dermatitis caused by allergy to rubber materials, and should be promptly consulted, and follow the doctor’s instructions for treatment with topical and oral medications. Some of the people who are allergic to rubber materials, after wearing rubber gloves, there will be an inflammatory reaction in the contact area, resulting in small blisters. The first step should be to detach and avoid contact with the sensitizing substance, and choose the appropriate medication according to the severity of the lesions. Hand lesions with blisters can be prescribed topical glycerine lotion, 3% boric acid solution wet compresses to promote convergence of blisters dry. When there is no obvious blister exudation, you can follow the doctor’s instructions for the external use of glucocorticoid drugs, such as mometasone furoate gel, Dinaid ointment. It is also necessary to combine the use of cetirizine and other anti-allergy drugs. Wearing rubber gloves with small blisters, should promptly go to the hospital dermatology department, by the doctor for targeted treatment. In addition, patients should pay attention to keep their hands dry, avoid squeezing small blisters, so as not to induce infection.