Headache after lumbar puncture is mainly related to low cerebrospinal fluid or cerebrospinal fluid leakage due to lumbar puncture and low cranial pressure. Treatment should be bed rest, decubitus lying, or too high bed end, a large number of rapid intravenous infusion of saline, to quickly make the cerebrospinal fluid to achieve equilibrium. The main thing is to carry out lumbar puncture when skillful operation, do not carry out a number of repetitions, which is easy to cause multiple parts of the dura mater to puncture, prone to complications. It is also necessary to carry out aseptic operation to reduce the chances of infection, which is more conducive to ensure that the headache is not caused by lumbar puncture infection, if the meningitis irritation symptoms caused by lumbar puncture infection, it is very difficult to treat.