Pernicious anemia can lead to spinal cord degeneration. 1. Pernicious anemia, caused by type A atrophic gastritis with internal factor deficiency, mostly seen in the stomach and gastric body, rare in the gastric sinus, the presence of autoantibodies in the patient’s body, such as mural cell antibodies, anti-internal factor antibodies, etc., gastric mucosal atrophy, internal factor secretion obstacles, ultimately leading to vitamin B12 absorption disorders. 2. Pernicious anemia with vitamin B12 deficiency, there will be neurological changes, such as lack of vitamin B12 will lead to subacute combined degenerative disease of the spinal cord, the main manifestations of generalized weakness, clumsiness of movement, unsteady walking, like stepping on cotton, lower limb vibration sense and position sense and other deep sensory loss, lower limb ataxia. If pernicious anemia leads to spinal cord degeneration, it is recommended to go to the hospital in time to improve the examination and give targeted treatment or therapy.