Elevated urine creatinine concentration in urine routine is commonly found in the following cases: First, the urine creatinine concentration is elevated due to the concentration of urine as a result of drinking less water; Second, physiological conditions, such as hunger and strenuous exercise, lead to increased muscle decomposition in the body, which leads to elevated urine creatinine. This is a physiological phenomenon, which is not harmful to the body; third, various chronic wasting diseases, which can also lead to elevated urine creatinine. However, generally speaking, the significance of elevated urine creatinine alone is not particularly significant. At present, the clinical measurement of urine creatinine is mainly used to do urine protein creatinine ratio or urine microalbumin creatinine ratio. These two ratios can exclude false positive urine protein due to concentrated urine. If the urine creatinine concentration is elevated in the urine routine, and all other items are normal, and there are no symptoms in oneself, it is usually not caused by the disease.