Coldness all over the body can be a physiologic factor. It may also be a precursor to infectious diseases, shock, hypothyroidism, anemia and other diseases. 1. Infectious diseases: Infectious diseases will have the symptom of cold body, such as sepsis, bacteremia and other diseases due to bacteria and toxins into the bloodstream to produce an inflammatory reaction, the body will appear cold, the body temperature rises. 2. Shock: Especially in hypovolemic shock, due to the lack of effective blood volume, the body will prioritize the blood supply to the brain, heart and other important organs, the skin and limbs will be cold due to the lack of blood supply. 3. Hypothyroidism: Patients with hypothyroidism will also have chills due to lower basal metabolic rate, which can be clearly diagnosed by thyroid hormone measurement and can be improved by active supplementation of thyroxine tablets. 4. Anemia: due to insufficient oxygen-carrying capacity of the body, patients with anemia will also have symptoms of coldness, often accompanied by pallor, weakness of the limbs, dizziness and dizziness. 56. Physiological factors: If you are in a cold environment, the peripheral circulation of the body will be slowed down, the symptoms of cold body. Therefore, the etiology of chills is very complex, need to be combined with the patient’s accompanying symptoms, improve the relevant examination to clarify the cause of the disease.