Sodium valproate is not recommended for use with quetiapine fumarate. Sodium valproate is a broad-spectrum antiepileptic drug commonly used in clinical practice, and is the drug of choice for grand mal seizures combined with petit mal seizures, and is additionally used to inhibit abnormal discharges in the thalamus. Its contraindications are severe hepatitis, sodium valproate allergy, etc.; adverse reactions are transient gastrointestinal reactions, tremor, drowsiness, etc.. Quetiapine fumarate tablets are commonly used in the treatment of schizophrenia and bipolar disorder, etc. It is a kind of antipsychotic drug. Its contraindications are those who are allergic to the active substance of quetiapine fumarate or any excipients and those who are contraindicated from combining with cytochrome P450 3A4 inhibitors; the adverse reactions are dizziness, dry mouth, somnolence, dyspepsia, epileptic seizures and so on. Oral sodium valproate patients are epileptic, and quetiapine fumarate may lead to the risk of seizures, so the above drugs are usually not recommended to take together. However, it is not excluded that there are special clinical circumstances that require their use together. Consultation with a medical professional or pharmacist is recommended for the specific application of the above drugs.