A sudden feeling of wanting to die, and a relatively low emotional response, unhappy, worried, slow brain response, and no hope or expectation for the future, low self-esteem, and no good plans for the future need to be considered as possible depression. Once depression is diagnosed, antidepressant treatment is needed, such as medication with new antidepressants, psychotherapy with cognitive-behavioral therapy and physical therapy with electroconvulsive therapy, or transcranial magnetic stimulation therapy. In the clinical treatment process, pharmacotherapy is the preferred treatment method, especially the application of pentraxin reuptake inhibitors, such as paroxetine, sertraline, fluoxetine, etc. The whole course of disease, adequate amount and full course of systemic treatment are emphasized. Pay attention to the assessment of adverse reactions and efficacy in the treatment process, which can achieve good therapeutic results, and pay attention to the changes in the condition during the treatment process to prevent rekindling or relapse to improve the cure rate of depression.