Stabbing pain in the anus with blood during bowel movement is considered to be related to anal fissure, hemorrhoids, rectal prolapse, and anal fistula. 1. Anal fissure: long-term constipation or diarrhea, anal canal stenosis, infection, etc. can easily cause anal fissure. Typical symptoms of anal fissure patients are pain in the anal area during bowel movement, blood in the stool and anal itching. 2. Hemorrhoids: the disease is related to the displacement of the anal cushion, varicose veins, etc. Some patients may have no symptoms, and some patients are accompanied by bleeding, perianal itching, perianal pain and other symptoms, which manifests itself as anal pain and blood in the anus during bowel movement. 3. Rectal prolapse: Rectal prolapse will cause some patients to have blood in the anus when having a bowel movement. The etiology of rectal prolapse is not completely clear, may be related to the theory of sliding hernia, intussusception, common manifestations of rectal prolapse, mucus stool, urgency, pain in the sacrococcygeal part of the anus, fecal incontinence, rectal bleeding, and so on. 4. anal fistula: most anal fistula caused by rectal perianal tube abscess, and poor diet, lifestyle habits are triggering factors. Patients are mainly manifested in the external mouth of the anal fistula persistent or intermittent flow of blood, mucus secretion, but also easy to accompany the perianal skin itching, perianal pain and other symptoms, so there will be anal pain in the bowel with blood phenomenon. It is recommended that patients with anal pain and blood in the stool consult a doctor for examination in order to clarify the disease and follow the doctor’s instructions, to avoid delaying the condition.