If a patient with hepatitis B has viral replication, it means that the patient is in the active stage of chronic viral hepatitis B. The patient needs to have further blood tests for liver function to see if the patient has elevated ghrelin and glutamic oxalacetic aminotransferase. If there is an elevation of glutathione and glutamic oxalacetic aminotransferase, combined with the replication of hepatitis B virus. This is the time to consider that the patient is in the window of viral replication, you can actively consider antiviral treatment, you can consider oral lamivudine, adefovir, entecavir and other drugs to actively antiviral treatment, you can also consider the injection of interferon for treatment. The general cycle of interferon injection is about six months to a year, and oral antiviral drugs need long-term adherence. After six months to a year of interferon injections, it is possible for some patients to turn negative or carriers. For some patients who take oral antiviral drugs, the patient’s viral replication can also be controlled after long-term medication. If the patient develops elevated glutamic and ghrelin enzymes and elevated bilirubin during treatment, hepatoprotective drugs should be given intravenously if necessary. In addition, patients should pay attention to rest and not to stay up late and not to exert themselves.