Withdrawal reactions may occur with sudden discontinuation of medication for bipolar disorder. Details are as follows: Sudden discontinuation of selective 5-hydroxytryptamine reuptake inhibitor (SSRI) medications used chronically in the treatment of bipolar disorder can produce a withdrawal reaction. The reason is that long-term use of SSRI sensitizes the 5-HT receptors in the brain to down-regulation, and when it is suddenly discontinued it decreases the concentration of 5-HT in the synaptic gap, and low neurological messaging causes dizziness, hypersomnolence, confusion, vivid dreams, increased neurological sensitivity, depression, nausea, etc., and is especially likely to be seen in paroxetine, which has a shorter half-life. Withdrawal reactions in newborns are also more common in pregnant women taking SSRIs. Such as crying after birth, spasticity, and high muscle tone. Therefore, when taking SSRIs for a long period of time and need to discontinue the drug, a gradual reduction of the dosage should be used and then terminated. If the drug is suddenly discontinued, it is recommended that family members accompany the patient to the hospital for a comprehensive standardized examination and ask the physician about the treatment plan, and reformulate the discontinuation plan.