After menopause, due to the significant reduction of estrogen in the body, the breasts, as the target organ of estrogen, no longer have the cyclical changes of enlargement and rejuvenation that occur with the menstrual cycle, and thus enter a relatively “quiet” period. Therefore, under normal circumstances, the breasts after menopause will gradually shrink due to the lack of estrogen stimulation, and the glands will gradually degenerate and be replaced by fatty tissues, manifesting as smaller breasts, flabby and sagging, and increased skin folds; moreover, the breast lumps caused by the original benign breast lesions will also shrink to varying degrees with the shrinking of the normal glands, and the periodic breast swelling and pain should also disappear. The periodic breast swelling and pain should disappear. If breast pain occurs again after menopause, breaking the “peace” of the breast, there may be several situations: First, during menopause before menopause, the secretion of endogenous estrogen is in a process of rapid reduction, and the breast tissue is not yet able to adapt to this change in hormone secretion, and each part of the breast reacts unevenly to the reduction of hormone. The response to the decrease in hormone secretion is not uniform and some corresponding changes may occur, such as localized pain, nodules or glandular thickening. This reaction may stop after menopause or may persist for a considerable period of time after menopause. As it is only a special reaction of a certain physiological period, there is no need to be afraid, as long as regular check-ups are carried out according to the doctor’s instructions and, if necessary, some medications for the treatment of menopausal syndrome in women can be effective. There is another situation that should be paid special attention, that is, breast pain occurs again after several years of menopause, which may be only vague pain, lumps may be palpable in the breast, or there may be no lumps palpable but only glandular thickening, at this time, it is often necessary to be alert to the possibility of early breast cancer and should not be taken seriously. Since postmenopausal women have entered the age group with a high incidence of breast cancer, it is important to strengthen surveillance and to pay high attention to patients with postmenopausal breast pain.