In general, magnesium valproate and lamotrigine can be co-administered. Both are antiepileptic drugs, and the combination can increase central nervous system inhibition, lowering the convulsive threshold and the anticonvulsant effect of valproic acid . Magnesium valproate has antiepileptic and antimanic effects, and can be used for the treatment of generalized or partial epilepsy, especially catatonic seizures, myoclonic seizures tonic spasticity seizures, dystonic seizures, etc.; manic seizures in bipolar disorder. Leukopenia and severe liver disease, porphyria, allergy to magnesium valproate is prohibited; thrombocytopenia patients, children and the elderly should be used with caution. Lamotrigine is mainly used for simple partial seizures, complex partial seizures, secondary generalized rigid clonic seizures and so on. Allergic to Lamotrigine, children under 2 years of age is prohibited; renal failure, severe hepatic impairment, pregnant and lactating women, the elderly should be used with caution. It should be noted that magnesium valproate inhibits lamotrigine glucuronidation, reduces the metabolism of lamotrigine and prolongs the half-life of lamotrigine, so the dosage of lamotrigine should be adjusted when the two are used together. The combination may increase central nervous system depression, lowering the convulsive threshold and the anticonvulsant effect of valproic acid . Valproate and Lamotrigine should be used in combination under the supervision of a physician and unauthorized use is prohibited.