Endometrial cancer in middle and late stages can be treated by different methods such as surgery, radiotherapy and chemotherapy. 1. Surgery: endometrial cancer is mainly treated by surgery, such as hysterectomy + double adnexa resection + tumor subtraction, tumor cell reduction with hysterectomy + double adnexa resection, which is often difficult to be operated directly in middle and late stages, radiotherapy or chemotherapy can be adopted first, and then evaluate whether surgery is possible again. 2. Radiotherapy: some patients with endometrial cancer in middle and late stages have lesions beyond the uterus but still confined to the pelvis, so they are not eligible for surgery, and can be treated with external irradiation radiotherapy, internal irradiation radiotherapy and chemotherapy. 3. Chemotherapy: chemotherapy is one of the common treatments for middle and advanced endometrial cancer, paclitaxel+carboplatin, docetaxel+carboplatin are the commonly used chemotherapy programs, which can be used for preoperative downstaging, postoperative adjuvant, palliative treatment and so on. Hormonal therapy such as tamoxifen and letrozole can also be applied according to the situation in the middle and late stages of endometrial cancer, and the specific methods are recommended to be selected and implemented under the guidance of doctors.