Hypoechoicity is an ultrasound description of a liver lesion that suggests the presence of abscesses, cysts, hemangiomas, fatty liver, and abnormal foci of space-occupying lesions such as hepatocellular carcinoma. Normal liver ultrasound describes a moderately echogenic liver with some blood vessels visible in the liver parenchyma, while hypoechoic describes the presence of intrahepatic calcified foci or stones. Hypoechoic areas seen on ultrasound may indicate liver abscesses, liver cysts, hepatic hemangiomas, heterogeneous fatty liver, and malignant neoplastic lesions. Usually, if hyperechoic area is found in ultrasound examination, it is necessary to further enhance CT or MRI examination, and perform liver puncture biopsy if necessary, to make a clear diagnosis and guide the treatment, so as to avoid misunderstanding the condition.