Sore bones at night may be caused by physiological factors such as overwork and cold, or by pathological causes such as autoimmune diseases and tumors. 1. Physiological reasons: long-term heavy physical labor can cause fatigue injury to the soft tissues around the bones. When sleeping at night, due to the parasympathetic innervation, the symptoms of bone pain can appear; in addition, staying in the air-conditioned room or blowing the fan for a long time, the spasm of small blood vessels around the bone can appear, resulting in the accumulation of metabolites, which can stimulate the nerve root and give rise to the symptoms of pain. 2. Pathological reasons: people with autoimmune disease, bone and joint can have perverse reaction, osteomalacia, synovial hyperplasia and deposition of immune complexes, etc. When sleeping, due to the slowing down of local blood circulation, the symptoms of bone soreness may also occur, such as rheumatism, rheumatoid, etc. Tumor patients, due to the high consumption rate of the organism, may have symptoms of bone soreness. Tumor patients may also experience this symptom due to the high consumption status of the body and bone metastasis. There may be other reasons for the bone pain at night, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.