The pain in the middle of the forefoot when walking can be caused by several reasons: first, plantar fasciitis, plantar fasciitis patients can have chronic inflammation of the plantar fascia, often due to cold, strain and strain, which should be investigated and diagnosed early, to exclude other diseases for early diagnosis and treatment. Second, metatarsophalangeal headitis, metatarsophalangeal headitis is due to chronic inflammation of the metatarsal head of the foot and leads to pain when walking, especially when walking with force, the pain is very obvious, then it is necessary to check the body and examine the foot x-ray to diagnose. Third, fatigue fracture, when the foot metatarsal bone has a fatigue fracture, can also have pain when walking in the middle of the forefoot, then to check the foot X-ray, CT to diagnose early. Fourth, tumors of the metatarsal bones of the feet, tumors of the metatarsal bones of the feet can also have pain when walking, then the foot MRI, CT to diagnose and treat.