Irbesartan and nifedipine extended-release tablets can’t make a good or bad evaluation of the effect of the drug, they have their own advantages and shortcomings. Irbesartan’s main role is to inhibit angiotensin II receptors, can reduce the generation of angiotensin in the body, is the main treatment of hypertension, for hypertension combined with renal insufficiency, cardiac insufficiency patients with better efficacy. Nifedipine extended-release tablets belong to the calcium antagonist, the drug in vivo on the peripheral arteries and coronary arteries have a dilating effect, the effect is better for the elderly patients, especially hypertension accompanied by coronary heart disease patients. The adverse reactions of Irbesartan are dizziness, postural hypotension, muscle pain, etc. It is forbidden for women who are allergic to the drug components, late pregnancy and pregnancy. Adverse reactions of nifedipine extended-release tablets include facial flushing, lower limb edema, dry stools, tachycardia, etc. It is contraindicated in patients who are allergic to the drug components, taking oral rifampicin, or with severe aortic stenosis. Irbesartan and nifedipine extended-release tablets have their own indications and contraindications, suitable for different groups of people, each has its own advantages, and it is not possible to make a direct evaluation of the effect of the two drugs, and the therapeutic effect can usually be achieved when the indications are met. Irbesartan and nifedipine are both prescription drugs, need to be used under the guidance of a doctor to avoid adverse consequences.