Gap pain in the middle of the knee can be caused by damage to the meniscus, anterior cruciate ligament and other structures around the knee. It can be relieved by physical therapy, functional exercise and medication. 1. Physiotherapy: Injury to the soft tissues, cartilage and other structures around the knee can lead to localized aseptic inflammation, such as hyperplasia and exudation, which can cause pain in the middle seam of the knee. In order to relieve the pain, infrared laser therapy, ultrasound therapy and other physical therapy can be used to promote local blood circulation and accelerate the metabolism of inflammatory substances. 2. Functional exercise: When the muscles and ligaments around the knee are not strong enough, exercise will cause pain in the middle knee joint. Therefore, you can strengthen the muscles around the knee joint through gradual knee flexion and extension exercises, aerial cycling exercises, straight leg raising and other exercises to maintain the stability of the knee joint and reduce the pain. 3. Medication: When there is obvious pain in the middle of the knee, you can take non-steroidal anti-inflammatory drugs such as ibuprofen under the guidance of a professional doctor to relieve the pain. Since there are many reasons for treating pain in the middle knee joint, it is recommended to visit a hospital for professional and appropriate treatment.