In the neck appear skin black, rough, touching like fluffy, clinically common in acanthosis nigricans, the pathogenesis is mainly related to genetics, obesity and endocrine disorders, such as excessive insulin levels or insulin resistance caused, in the treatment of specific methods are as follows: First, need to control weight, reduce weight, you can choose a mixture of retinoic acid ointment and urea vitamin E cream for external use, or topical salicylic acid ointment. Secondly, it is necessary to go to the endocrinology department to regulate insulin level. After the insulin level is regulated normally, acanthosis nigricans may be relieved and cured quickly. Then, you can go to the regular tertiary hospital dermatology department for medical aesthetic treatment, such as photorejuvenation laser treatment, picosecond and super picosecond treatment, after the above treatment, the skin darkness and roughness can be quickly relieved and cured. Finally, patients with increasingly obvious and aggravated skin darkness and roughness are recommended to go to dermatology for review of tumor screening tests to exclude malignant tumors. Therefore, for skin darkness and roughness, patients are recommended to go to regular hospitals for corresponding treatment under the guidance of dermatologists.