The amount of urine protein is not directly related to uremia, which means that uremia cannot be diagnosed from urine protein quantification, but rather the diagnosis is confirmed based on creatinine or glomerular filtration rate. Uremia is the final regression of chronic kidney disease and can be diagnosed if creatinine exceeds 707 μmol/L, while high protein amount is the basis for diagnosing chronic nephritis or nephrotic syndrome. When urine protein is high, accompanied by edema and hypertension, it is usually chronic nephritis. If the protein amount reaches 3.5g, it is a patient with nephrotic syndrome, while the creatinine and glomerular filtration rate of the patient are basically normal at this time. Some patients with uremia have only a small amount of proteinuria in 24 hours, but creatinine is more than 707μmol/L, which is also uremia at this time. Therefore, urine protein is an indicator of kidney damage, but not a basis for the diagnosis of uremia.