Bilobar thyroid nodules, benign on one side and malignant on the other, require aggressive treatment. Patients can be treated with lobectomy, or total thyroidectomy, and radionuclide therapy. Medication. If the bilobar thyroid nodule appears benign on one side and malignant on the other, and the nodule on the malignant side does not have distant metastases or extra-thyroidal invasion, and there is usually no history of radiation therapy to the neck of the patient, the type of malignant pathology, and the diameter of the thyroid mass is less than 1 cm, the malignant side of the thyroid can be treated with adenohypophyseal lobectomy. If the malignant side of the thyroid nodule appears to have distant or lymph node metastasis, extra-thyroidal invasion; the diameter of the mass is more than 4cm; the thyroid gland appears to be columnar cell type, diffuse sclerosis and other adverse pathologic types; and the history of radiation to the neck. If the patient’s malignant thyroid nodule fulfills one of the above criteria, total thyroidectomy is required. It is recommended that patients with bilobar thyroid nodules, one benign and one malignant, should seek prompt medical attention and treatment as prescribed.