Gastroscopy can be divided into painless gastroscopy and ordinary gastroscopy, painless gastroscopy is more comfortable, most of the people can tolerate; ordinary gastroscopy is less comfortable, whether it can be tolerated with the individual’s physical fitness, the doctor’s operation techniques and other factors, if the young patients can generally tolerate, the older patients are more difficult to tolerate. During painless gastroscopy, the patient is under anesthesia and will not feel pain and other uncomfortable symptoms, most of the patients can tolerate painless gastroscopy. However, during ordinary gastroscopy, the patient is awake and may experience nausea, vomiting, stomach tugging and other discomforts during the operation; whether or not the patient can tolerate it has to do with the individual’s physical fitness, the doctor’s operation technique and other factors; if the patient is young, he/she will be easier to tolerate it, whereas older patients will be more difficult to tolerate it; the doctor’s operation technique will be easier to tolerate it when it is gentle. Patients who need to undergo gastroscopy should actively cooperate with the doctor’s operation and indicate any discomfort in time.