The difference between clindamycin and penicillin lies in the category, efficacy and so on, belonging to different types of antibiotics, treating diseases and bacterial spectrum are different. 1. Category: Although both clindamycin and penicillin belong to antibiotics, clindamycin belongs to lincosamide antibiotics, which is a separate type of antibiotics. And penicillin belongs to beta lactam antibiotics, mainly amoxicillin, cloxacillin, benzathine and other drugs. 2. Efficacy: Clindamycin is mainly used for gram-positive bacterial infections resulting in tonsillitis, acute bronchitis, acute urethritis and other diseases, as well as anaerobic bacterial infections caused by lung abscesses, peritonitis, endometritis and other diseases. Penicillin, on the other hand, is mainly used for diseases caused by sensitive bacteria or sensitive pathogens, such as gram-positive bacteria, Streptococcus pneumoniae, gonococcus, and other infections, such as pharyngitis, scarlet fever, pneumonia, and other diseases. The difference between clindamycin and penicillin is large, the patient should should consult the doctor before using the medicine, follow the doctor’s instructions to use the medicine, not blindly use the medicine.