Patients who are allergic to antibiotics need to identify what antibiotic they are allergic to. If the patient was previously allergic to penicillin, it is usually necessary to avoid the use of penicillin and replace the treatment with other types of antibiotics. For patients with colds or inflammatory infections, a routine blood test should be performed to see if the patient’s white blood cells and neutrophils are elevated. If there is an elevation of leukocytes and neutrophils, the patient has fever, and the oral medication is not effective, intravenous antibiotics should be considered for antibacterial treatment. The appropriate antibiotic is selected based on the patient’s allergy history. If body fluids, such as the patient’s sputum or secretions from the body surface area, can be obtained, bacterial culture as well as drug sensitivity tests can be performed. Initially, patients can be treated empirically with broad-spectrum antibiotics for anti-inflammatory treatment. After the results of the drug sensitivity test are available, the patient can select a sensitive antibiotic for aggressive anti-inflammatory treatment based on the results of the drug sensitivity test. Usually patients who are not allergic after the skin test can be treated aggressively with that antibiotic. However, if the patient is allergic to multiple antibiotics, he or she can also choose macrolide antibiotics for intravenous infusion treatment.