Separation of nail and flesh means separation of nail and flesh, which is not serious if it is caused by trauma or onychomycosis, but more serious if it is caused by malignant melanoma. 1. Trauma: nails are severely crushed or hit by external force, which will lead to bruising in the nail area and cause separation of the nail bed, and the nails will grow back as the patient recovers. 2. ringworm of the nail: ringworm of the nail is mainly due to the nail bed or nail plate by the skin ringworm bacteria caused by the violation of the nail lesions, this disease will cause patients with nail plate discoloration, brittle, shedding of the situation, the patient can be under the guidance of the doctor using itraconazole, terbinafine and other drugs for treatment. 3. Malignant melanoma: malignant melanoma occurs in the end of the finger will lead to nail loss, this situation is more serious, easy to metastasize and spread the situation, need timely treatment. If the nail and flesh are separated for a long period of time, you should consult a doctor in time for examination.