Thickening of the gallbladder wall and cholesterol deposition need to be improved by dietary modification, lifestyle modification, medication and surgery depending on the severity of the condition. 1. Dietary modification: Reduce the intake of high cholesterol and high fat food, and have a light and balanced diet with low salt, low fat and low sugar. 2. Lifestyle management: Participate in more physical exercise; develop the habit of drinking water regularly; quit smoking and drinking; avoid staying up late for a long time. 3. Drug treatment: you can take choleretic drugs, such as ursodeoxycholic acid and adenosylmethionine, which can effectively improve the symptoms of cholesterol deposition. 4. Surgery: For patients with more serious conditions and poor results of conservative treatment, surgery can be used to remove the treatment. The above drugs can have gastrointestinal discomfort, skin rash and other adverse reactions, when using, must be strictly in accordance with medical advice under the guidance of a doctor.