Indirect bilirubin of 52 μmol/L has reached the range of serious indicators. Indirect bilirubin, also known as unconjugated bilirubin, is derived from the destruction of red blood cells, has not been gluconated in the liver, and is fat-soluble. Its reference value ranges from 1.7 to 10.2 μmol/L. Therefore, an indirect bilirubin of 52 μmol/L has exceeded the reference value by more than two times and has clinical reference significance. High indirect bilirubin is commonly found in prehepatic or hepatic diseases, such as hepatitis and cirrhosis, hemolytic disease, infantile breast milk jaundice, and blood transfusion error. In addition to this, excessive alcohol consumption can lead to elevated indirect bilirubin. However, the clinical significance indicated by elevated indirect bilirubin cannot be determined by one indicator alone, but requires a combination of indicators. If the indirect bilirubin reaches 52 μmol/L, you should go to the hospital for medical consultation to identify the cause of the disease under the guidance of the doctor and give targeted treatment or standardized treatment.