Uremia is the end stage of chronic renal failure can accumulate multiple systems, causing dysfunction and complications of multiple systems, mainly: i. In terms of water electrolyte acid-base metabolism disorders, patients will develop edema, hyperkalemia and metabolic acidosis; ii. In terms of the respiratory system, patients will develop pulmonary edema, metastatic calcification of the lungs, and pleural effusion; iii. In terms of the circulatory system, patients will develop hypertension, left ventricular hypertrophy, heart failure and pericardial effusion, etc.; four, in the digestive system, patients will develop esophagitis, gastritis, peptic ulcer, peptic hemorrhage, ascites, etc.; five, in the hematologic system, patients will develop anemia and thrombocytopenia, etc.; six, in the urinary system, patients will develop acquired renal cysts and urinary stones and infections, etc.; seven, in the rheumatologic disorders, patients will develop gout and renal bone disease, etc.; eight, Neurological aspects, patients will develop uremic encephalopathy, cerebrovascular disease, peripheral neuropathy, autonomic neuropathy and neuropsychiatric abnormalities; ix. Skin complications, patients will develop yellow or yellowish-brown skin, itchy skin and so on.