Whether or not the blood sugar will drop when taking hypoglycemic drugs depends mainly on the patient’s pancreatic function and whether the choice of hypoglycemic drugs is appropriate, and it is recommended to take the drugs under the guidance of a doctor. When there is obvious insulin resistance in patients with type 2 diabetes mellitus, the choice of drugs such as metformin and pioglitazone can often improve insulin, increase insulin sensitivity and reduce blood glucose. Type 1 diabetes mellitus or type 2 diabetes mellitus advanced islet function is poor patients, choose insulin promoter such as glimepiride is usually unable to reduce blood sugar, then the main choice of insulin to lower sugar. Therefore, diabetic patients need to be under the guidance of a doctor to choose hypoglycemic drugs, endocrinologists specializing in endocrinology according to the pancreatic islet function and other conditions to determine the better effect of lowering glucose, while taking these hypoglycemic drugs need to pay attention to the adverse effects of the drug.