Cranial repair is a common surgical procedure to repair cranial defects caused by various reasons using certain cranial bone replacement materials to repair the defective area. Cranial repair surgery is widely used in neurosurgery, because cranial defect is a common disorder, cranial trauma may leave cranial defect, treatment of cerebral hemorrhage may require decompression of bone flap while removing hematoma, surgical treatment of brain tumor may also lead to cranial defect, and cranial lesion itself, all of which require cranial repair. The more important point of cranial repair surgery is the selection of repair material. For a long period of time, titanium mesh was the widely used material for skull repair in most hospitals, but it was found that there are certain problems in clinical use, such as rejection, which is not high, but can be very troublesome once it happens. What are the cases of rejection of titanium mesh for skull repair? The rejection phenomenon is mainly related to the individual’s constitution, mainly to the characteristics of the immune system, that is, the compatibility of human tissues with the titanium mesh metal material. However, there are still a few people with special constitution and strong sensitivity of immune system, which may treat the titanium mesh material implanted in human body as a foreign body and make rejection reaction, the stability of titanium mesh metal material is very strong, so the rejection will not cause damage to the titanium mesh, and the result is only the human body itself can be injured, mainly manifested as scalp tissue damage, even causing material exposure. . Of course, in addition to the phenomenon of rejection, titanium mesh material may also have other problems, such as post-operative infection, wear and tear of the scalp, which can also cause material exposure, as well as affect the CT magnetic resonance examination, strong thermal conductivity, sensitivity to external hot and cold environment, discomfort, poor shaping effect, etc.. Therefore, the use of titanium mesh to repair the skull is not very recommended at present. What material to use? In recent years, a new type of special polymer material has emerged – polyetheretherketone PEEK, which is highly histocompatible and has not been found to have rejection cases. Other properties are also excellent and can well overcome the above-mentioned problems that may arise with titanium mesh materials, and it is gradually becoming a new trend in cranial repair materials. Our team is currently using polyether ether ketone PEEK as an advanced cranial repair material, and we are constantly improving and upgrading our technology, as well as innovatively introducing the concept of cosmetic surgery, so that we can carry out comprehensive PEEK cranioplasty to achieve good clinical results.