When itchy skin occurs due to a decrease in immunity, the first step in clinical treatment is to improve the immunity of the body. If the immune deficiency is more serious, such as the presence of malignant tumors, coronary heart disease, angina pectoris, heart failure, and diabetes. While treating the primary disease, it is necessary to administer thin glucose peptide injection or sodium deoxynucleotide injection, and also intramuscular injection of BCG polysaccharide nucleic acid injection, and also with pidomod oral solution, mushroom mushroom polysaccharide tablets, and thymidine enteric capsule. In addition, orotadine hydrochloride tablets or loratadine citrate capsules can be applied orally for symptomatic antipruritic treatment.