Azithromycin and statins should not be taken at the same time. Azithromycin belongs to the second generation of macrolide antibiotics, which interferes with the metabolism of statins, thus increasing the chance of adverse reactions to statins, and therefore cannot be taken at the same time as statins. Statins include a variety of drugs, such as atorvastatin and simvastatin. Statins are inhibitors of key enzymes of cholesterol synthesis and are mainly used for lipid-lowering therapy in patients with hypercholesterolemia and coronary heart disease. They are contraindicated in people who are allergic to statins, pregnant and lactating women, and people with severe liver or kidney impairment. Myalgia, myopathy, and hepatic impairment may occur after statin administration. Azithromycin is suitable for the treatment of acute pharyngitis and acute tonsillitis caused by Streptococcus pyogenes, as well as sinusitis, otitis media and other infectious diseases caused by sensitive bacteria. It is contraindicated for those who are allergic to macrolide antibiotics, and those with hepatic insufficiency. Adverse reactions such as dyspepsia, gastrointestinal flatulence, gastritis, headache, drowsiness, skin rash may occur after use. Consult a professional doctor before using the drug.