We all know that selenium is a trace element required by the human body, precisely because it is a trace element, so there is a possibility that it is not supplemented in daily life, which will lead to a series of symptoms of selenium deficiency, below we will give you a detailed introduction to the tests related to selenium deficiency. Selenium deficiency requires laboratory tests Bone x-ray radiographs, which help to diagnose. It is a disease caused by insufficient intake of selenium. Clinically, it mainly presents with cardiac symptoms and joint symptoms, the former being Keshan disease, which is divided into four types: acute type, subacute type, slow type and potential type. The acute type, with rapid onset, is characterized by cardiogenic shock; the subacute type, mostly seen in children, can develop chronic congestive heart failure or cardiogenic shock after 1 week of onset; the slow type, with a slow course, is characterized by chronic congestive heart failure; the latent type, mostly without specific symptoms, has a mildly enlarged heart. The latter type, i.e., large osteoarthrosis, is characterized by chronic lesions of the bones and joints of the extremities, with initial fatigue, bone and joint pain, followed by thickening of the joints, flexion difficulties, muscle atrophy, joint contracture, short limbs (fingers) and short body size. Bone X-ray radiographs, help to diagnose. 1, blood selenium concentration measurement:<10 micrograms/dl (μg/dl), can cause the disease. 2, glutathione peroxidase (GSH-PX) activity measurement:activity is reduced. Selenium deficiency test items: Peroxidase staining (POX) Serum selenium (Se) Peroxidase staining (POX) (normal value and its clinical significance) 1, positive: blue-green granules are seen in the cell plasma, according to the number of granules can be divided into strong positive (common in all stages of cells below early granulocytes and eosinophils), positive (common in a few macrophages), weak positive (common in infantile and mature monocytes). 2. Negative: cells without blue-green granules in the cytoplasm. Clinical significance: It helps in the differential diagnosis of acute leukemia. For example, acute lymphoblastic leukemia (ALL) is negative and acute non-lymphoblastic leukemia (ANLL) is positive, among which acute monocytic leukemia (Ms) is mostly seen as weakly positive; promyelocytic leukemia (M3) is mainly strong positive, etc. Serum selenium (Se) (normal value and its clinical significance) Normal value: Atomic absorption method: 1.02~2.29 µM/L Clinical significance: Increased: Commonly seen in selenium poisoning (certain occupational environments can cause increased blood selenium concentration). Decrease:Common in Keshan disease, hemolytic anemia, ischemic heart disease, liver cirrhosis, etc.