Corneal infection is manifested as corneal fungal moss or ulcers, subcutaneous tissue type dark filamentous mycosis can be seen in the subcutaneous tissue with thin pus, cysts with exudate, if the cyst wall excision is incomplete, leaving a sinus tract, can not heal for a long time. Dark filamentous mycosis is a group of dark fungi caused by the tissue with dark mycelium as a characteristic of the skin, subcutaneous tissue or systemic infection. 1974 Ajello proposed this name. Dark colored mycosis has been reported in scattered cases around the world, but mostly seen in the tropics. In recent years in Shandong, northeast China and Zhanjiang and other places there are reports of disseminated cases. Pathogenic route is mainly exogenous infection and conditional pathogenic infection. The route of infection may be the implantation of the pathogenic fungus through a skin break or inhalation of fungal spores. Clinical manifestations are superficial ulcers, petechiae, brownish-black spots or wart-like growths with slight itching or mild swelling and pain, and some may have no conscious symptoms. Diagnosis relies on mycological examination and histopathological examination. Most of them are not sensitive to antifungal drugs and have poor efficacy. What are the preventive methods for corneal fungal moss or ulcers? First, prevention attention to improve the body’s immunity, especially cellular immunity, can use immunomodulatory drugs. In addition, whether it is infectious or non-infectious skin disease, as long as the skin has scratching symptoms or inflammatory lesions, in the diet should generally be cautious of seafood, eggs, beans and irritating diet, other animal protein, when the symptoms are serious should not be used more. Salt has the disadvantage of retaining water to make itching and inflammation increase, so a light diet should be taken when inflammation is severe. The diet is closely related to the prevention and treatment of skin diseases. Second, treatment 1, local treatment: for limited skin, subcutaneous damage, as well as keratitis and sinusitis should be surgically removed, but intact, to avoid re-implantation of the bacteria. In addition, local heating therapy can also be applied. Black hair nodular disease is commonly treated by shaving the hairs or washing the hairs daily and scraping the nodules by hand. Can shave the hair and then use some antifungal agents (such as 0.05% mercuric chloride, 6% salicylic acid, 12% benzoic acid, 3% sulfur or 2% formaldehyde solution), can be cured. It can also be washed with a solution containing ketoconazole and selenium disulfide. Topical treatment of black spots on the palm can often be effective. Imidazole creams are particularly effective, applied externally 2 to 3 times a day for 2 weeks. Miconazole and clotrimazole creams are effective for the treatment of parapatellar and plantar lesions. Miconazole is effective for the treatment of foot lesions. Keratolytic agents (such as 10% sulfur cream, 6% salicylic acid, 12% benzoic acid ointment or tincture) are often effective for the treatment of the disease. 2, systemic treatment: suitable for systemic damage, surgery can not be removed cases. Most of the antifungal drugs are not sensitive, the efficacy is poor, requiring long-term, large amounts of medication. Infection caused by external vial mold, flucytosine, fluconazole and amphotericin B effect is better. Hairy branch spore mold infection is only more sensitive to flucytosine, can be used in combination with amphotericin B. Recently, itraconazole and terbinafine are also used in the treatment of this disease, but still need to accumulate experience. Third, the prognosis of systemic dark sporotrichosis prognosis is poor, often leading to death.