Low-grade vesicoureteral reflux, especially in infants (less than one year old), does not necessarily require surgery and can be managed or reduced with medication first, as described below and with the following precautions. The theory behind prophylactic antibiotics is that vesicoureteral reflux does not cause any damage to the kidneys as long as the urinary tract is not infected. The method is: ingesting a small amount of prophylactic antibiotics every night. Commonly used antibiotics are: 1. Sulfamethoxazole: the most commonly used drug. Dose for babies, 0.2 mg/kg body weight per night. Side effects are rare. 2, Amoxicillin Amoxicillin, infants under two months of age, liver metabolism is not yet mature. Sulfamethoxazole is not recommended. Amoxicillin can be used. It is also very safe. 3. Furantoin, can also be used. In high doses, it may cause pulmonary fibrosis, but preventive doses are still safe. The taste is not tasty, some children do not like. 4, there are also attempts to use probiotics to reduce the infection. Bacteria to suppress bacteria, that is, the traditional Chinese saying “fight poison with poison”. The effect is still under study. Antibiotics can reduce nephritis, but the efficiency is not as high as surgery, if eating prophylactic antibiotics still have urinary tract infection (breakthrough infection), it is possible that the medication is not taken on time, there may be too much bladder urine or the dose of drugs is too high, both will cause resistance. In this case, surgery for reflux should be done.