Many pregnant women often feel various discomforts during pregnancy, including itching of the belly. Physiologic and pathologic causes of belly itching can be distinguished. Physiological causes include the rapid thinning of the abdominal skin due to the rapid growth of the abdomen during pregnancy, which results in the barrier effect of the abdominal skin being damaged. It is therefore susceptible to external stimuli that can irritate the cutaneous nerves of the abdominal skin, leading to itching. In addition, it is also necessary to consider pathological causes, such as pregnant women with diabetes or other systemic diseases, may lead to the persistence of itchy belly symptoms stubborn. In the case of belly itching in pregnant women, it is important to differentiate between the etiologic causes; for physiologic ones, most believe that the symptoms can be relieved at the end of the pregnancy. If the patient has a pathologic cause, it is important to target the patient’s disease for eradication.