The prevention of occupational diseases has the principle of three levels of prevention, and the prevention of occupational poisoning should also follow the principle of three levels of prevention. Take comprehensive prevention and control measures, mainly in several aspects: 1. Organization and management measures: leaders at all levels of the enterprise should pay attention to the top of the mind, implement relevant national regulations and policies in the work, and establish corresponding organizational leadership institutions in the management, develop preventive measures and safety operation procedures, and implement them; 2. Eliminate toxic substances: through science and technology and process reform, use non-toxic or low-toxic substances instead of toxic or highly toxic substances, such as using xylene instead of benzene as solvent or diluent; 3. Reduce the concentration of toxic substances: adopt engineering and technical measures to reduce the concentration of toxic substances in the workplace to meet the requirements of occupational health standards; 4. Do a good job in personal protection and personal hygiene: individual protection is not a fundamental measure in the prevention of occupational poisoning, but in many cases, it is an important auxiliary measure, such as contact with strong acid and alkali, it is necessary to provide staff with acid and alkali resistant work clothes, and to equip anti-toxic masks and gas masks for some toxic operations. In addition, it is necessary to maintain good personal hygiene to reduce the chance of toxic work. Set up sanitary facilities, such as hand washing, shower, changing room and other sanitary work facilities; 5, enhance physical fitness: through appropriate strengthening of nutrition, physical exercise, pay attention to the combination of work and rest, to improve the body’s resistance; 6, strict monitoring and inspection: strict monitoring of the concentration of toxic substances in the workplace, monitoring and health inspection of biological materials, and regularly reduce the concentration of toxic substances in the air of the workplace, while keeping it below the occupational Exposure limits below, to implement pre-employment health checks, to exclude occupational contraindications, and prohibit participation in toxicological operations. In addition, to adhere to regular health checks: to achieve early detection of personal health conditions and timely treatment.