Calluses on the hands can be removed by topical application of medication or scalpel removal. Callus is mostly due to the skin long time friction caused by the thick layer of stratum corneum, manifested as skin thickening and hardening. 1. Topical application of medication: follow the doctor’s instructions for local application of medication, such as vitamin A cream, which has the efficacy of exfoliation, and is suitable for patients with mild symptoms. 2. Scalpel removal: patients with hand calluses too thick, too hard, has affected the daily life, you can go to the hospital for treatment, surgical removal of the surface layer of keratin. Hands with calluses daily can often use warm water to soak the affected area, wash your hands after applying moisturizing cream, keep the skin soft and moist, do not use a knife, scissors, etc. to trim the callus, peeling, may be secondary to infection, further aggravate the condition. Hand calluses, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor treatment.