Bleeding from a durian puncture is usually not harmful and should be sterilized to avoid infection. The shell of durian is hard and may prick the skin when consumed. There are no toxic or harmful substances in the shell of durian, so patients need not be overly nervous after being stabbed by durian. If the wound is not deep, patients can use iodophor and other drugs to disinfect it, and then bandage it. If the wound is deeper and there are residues in the wound, the patient should go to the hospital in time to remove the residues of durian shells with sterile instruments, and then use saline to rinse the wound and apply iodine povine to sterilize it for bandaging. The patient should follow the doctor’s instructions, change the medicine regularly, to avoid infection and inflammation of the wound. After bleeding from a durian wound, patients do not need to worry too much. If the wound becomes uncomfortable, they should seek medical treatment promptly.