Clinically, for acute cerebral hemorrhage, whether mannitol can be applied depends mainly on the condition of the patient’s cerebral hemorrhage and intracranial pressure. Generally speaking, if the patient has severe headache, projectile vomiting, the examination shows papilledema, the patient has coma, the possibility of cerebral herniation, then the intracranial pressure increase is very obvious, and it is necessary to give the patient immediate treatment to lower the cranial pressure, and mannitol is definitely the first choice. And sometimes if mannitol does not improve, it may be necessary to apply some hormones, diuretics, or even immediately take the surgical way to decompress the bone flap, in order to save the patient’s life, and at this time mannitol must be applied. However, if the patient’s general bleeding is relatively light, mannitol is not recommended. Because this time the patient does not have obvious signs of increased intracranial pressure, if the use of mannitol may reduce intracranial pressure. At this time, the loss of intracranial pressure limitation, on the contrary, may lead to increased bleeding. Therefore, at this time, some mild cranial pressure lowering drugs can still be used, such as glycerol fructose.