I don’t know whether it is because they mistake female hormones for hormones in general or they don’t understand the importance of female hormones to women, but there are always some female friends who are resistant to hormones and have a lot of doubts, and even talk about hormones, which affects the effective treatment of diseases. Zhao Qian of the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Zhengzhou University strictly speaking, the hormones usually referred to are hormones of adrenal gland origin, mainly glucocorticoids, and although taking them for a long time can cause “round moon face and buffalo back” kind of changes, as well as being prone to infections and not being able to stop taking them suddenly, these drugs are still used to treat certain diseases such as autoimmune diseases and serious diseases. However, these drugs are still good for treating certain diseases such as autoimmune diseases, severe allergic reactions, adrenal hypofunction and many other diseases, and cannot be replaced by any other drugs. The hormones referred to in the field of obstetrics and gynecology are different from the adrenocorticotropic hormones mentioned above, i.e. hormones in the general sense, but female hormones. Female hormones mainly refer to estrogen, in addition to progesterone and androgens that may be involved. Estrogen and progesterone are mainly secreted by the ovaries under the regulation of hypothalamus and pituitary gland. Androgens can be secreted by the adrenal glands in addition to the ovaries. The normal regulation of female hormones is indispensable throughout a woman’s life. The female life span consists of childhood before puberty, adolescence, sexual maturity, menopausal transition or menopause, and postmenopause (including old age). The female reproductive organs develop slowly before puberty and are basically in an infantile state. The amount of hormones secreted by the ovaries is very small but tends to increase gradually, so we can call it a sleeping woman. At puberty, the sleeping beauty awakens, and in addition to accelerated growth of muscles, bones and internal organs, sexual organs and secondary sexual characteristics also develop rapidly. Estrogen is like a messenger that brings the message of spring; it is also like a spring rain that moistens this virgin land. She promotes the development of female reproductive organs, thickening of labia, lengthening of vagina, fullness of uterus, maturation of ovaries, fullness of breasts and growth of body hair. The awakened beauty proudly tells her mother with her first menstruation that she is beginning to mature sexually. The first menstruation of a teenage girl is called menarche and is one of the important indicators of the onset of puberty and a sign of the beginning of sexual maturity. These are dependent on the action of female hormones. The ovarian function is still unstable at the time of menarche, and the menstrual cycle is not always regular, some cycles are very short, about 20 days; some cycles are very long, even several months; the bleeding time is long or short; the amount of bleeding is more or less. It takes about 1 to 2 years for some girls to have monthly periods. In some cases, the bleeding time is too long and the amount is too much, resulting in anemia and dizziness and panic due to the central maturation defect during puberty, which is pubertal gongbao. The period of sexual maturity, that is, the reproductive period, is the period of mature ovarian function. The hormone function secreted by the ovaries is more stable and vigorous, which is manifested by the establishment of regular cyclic ovulation and menstruation, and the reproductive organs and breasts undergo cyclic changes under the action of sex hormones secreted by the ovaries, so it is also the period of the most vigorous reproductive function. During this period, women are as bright and beautiful as a blossoming flower. Female hormone levels can also be disrupted, manifesting as non-ovulatory sterility and abnormal menstruation. If the ovaries do not secrete hormones or secrete low hormones before the age of 40, the ovaries are prematurely failing. Puberty is the period when sex hormones are from absent to present, while menopause is the opposite, from present to absent (less), but brings similar effects, so that menstrual disorders can also occur, and it is precisely the arrival of menopause that makes some women not pay attention to menstrual disorders, some bleeding in small amounts after several months of menopause, some bleeding in large amounts and for a long time, but also do not take it seriously, some vaginal bleeding dripping, ten days or even a month or Most people think that it is normal, and some people do not go to the hospital even if they have anemia. In addition to menstrual changes, recent and long-term symptoms may occur, such as flushing, hot flashes, sweating, vaginal dryness, mood instability, irritability or depression, insomnia, sensory disturbances, headache and dizziness, memory loss, osteoporosis, and Alzheimer’s disease (the main type of dementia). The decline of sex hormones brings about an imbalance of body and mind, and a series of physical and psychological symptoms caused by fluctuation or decrease of sex hormones around menopause are called “perimenopausal syndrome”, i.e. menopause syndrome, and some people may even seriously affect their daily work and life. Therefore, throughout a woman’s life, she cannot live without the proper regulation of female hormones. Therefore, female hormone is a good medicine to treat certain female diseases. For example, in the case of pubertal blood flow, it is often necessary to use drugs containing female hormones to treat including stopping bleeding and adjusting the regular menstrual cycle. It is important to pay attention to pubertal hematemesis because it can not only cause physical damage, such as anemia, infection, reduced body resistance, etc., but also affect study and life in serious cases, and also cause great psychological burden to women, producing anxiety, tension and fear. Some careless mothers do not remember their daughters’ menstrual cycle, and only remember to care when a heavy bleeding or continuous bleeding occurs after several months of no menstruation; there are also painful lessons of anemia and shock caused by untimely treatment of adolescent gonorrhea, and medication is ineffective to stop the bleeding by scraping. Some parents do not pay attention to adjusting their daughters’ menstruation, thinking that it is normal for little girls to have irregular menstruation, and that they will naturally get better after a few years, and even fear hormone treatment by doctors, so to speak, and refuse treatment because of this. Only by supplementing the deficiency of hormone levels in the body with estrogen and progesterone can a normal menstrual cycle be established. Therefore, we would like to remind mothers that they should pay more attention to their daughters’ reproductive health while caring for their daughters’ nutrition and physical development. Reproductive health during adolescence not only affects the physical health of adolescence, but also can affect the reproductive function of women in the future. For women in their reproductive years, the application of contraceptive pills containing estrogen and progestin components can often also inhibit ovulation and achieve the purpose of contraception. The pill is one of the main means of contraception for women in developed countries, but relatively few people in China choose the pill for contraception, probably based on their fear of hormones. Especially for polycystic ovary syndrome, which threatens fertility, oral contraceptives are often taken to restore the abnormal hormone levels in the patient’s body to a normal state. For patients with perimenopausal menstrual disorders, guidance and treatment should be provided. For menopausal transitional hemorrhage, the principles are to stop bleeding, adjust the cycle, reduce menstrual flow and prevent endometrial lesions; for patients with perimenopausal syndrome, in addition to general conditioning such as reasonable diet, emotional adjustment and appropriate exercise, pharmacological treatment – sex hormone therapy is also required if necessary; and For patients with premature ovarian failure, female hormone therapy is undoubtedly the best treatment modality and the one that benefits women the most. In clinical practice, we have seen many patients and family members with premature ovarian failure who have great doubts about hormone supplementation therapy, are overly suspicious of the adverse effects of hormones, and even stop treatment privately or do not standardize treatment, because they talk about “hormones”. Of course, the use of sex hormones to stop bleeding and adjust menstrual cycles requires the selection of appropriate preparations and methods of use according to the amount of bleeding. For patients with small amount of bleeding, the lowest effective dose of hormone should be used to reduce the side effects of the drug. For patients with massive bleeding, sex hormone therapy is required to be effective within 8 hours and the bleeding is basically stopped within 24 to 48 hours. Dosing includes a combination of drugs (estrogen and progestin or with androgens), and sex hormones alone (estrogen or progestin or androgens). Another point that both patients and doctors tend to overlook is that individual patients who do not follow medical advice and do not use medication systematically may experience menstrual disorders again, which may add to the problem and aggravate the condition and even confuse the diagnosis. The dosage and dosing regimen of sex hormone therapy for menopausal syndrome should be individualized, with the smallest and most effective dosage for a short period of time, and the indications should be chosen to avoid contraindications. The treatment should be started after the beginning of ovarian function decline and the appearance of menopausal symptoms, and the treatment period should be 3-5 years. Treatment must be under medical supervision and must be evaluated periodically so that the benefits clearly outweigh the risks before continued use. When discontinuing estrogen therapy, it is generally advocated that the dose should be slowly reduced or intermittently administered, with gradual discontinuation to prevent recurrence of symptoms. Combination of estrogen and progestin is emphasized for those with a uterus and can reduce the risk of endometrial cancer. Some data show that combined estrogen and progestin therapy for more than 5 years can increase the risk of breast cancer. We hope that patients and their families can understand female hormones correctly and stop looking at them differently, and never talk about them again. This article is authorized by Dr. Qian Zhao, please do not reproduce without authorization.