Creatinine 260umol/L represents creatinine exceeding the upper limit of normal value, which usually indicates impaired kidney function. The causes of elevated creatinine can be physiologic and pathologic factors. Physiological factors, such as excessive consumption of large amount of meat, leading to the accumulation of muscle metabolites in the body, may lead to creatinine elevation. Pathological factors, such as acute and chronic glomerulonephritis and other causes of kidney damage, resulting in the body’s metabolic waste can not be excreted through the kidneys, creatinine will increase. Usually, creatinine of 260umol/L indicates that the patient enters the stage 3 of chronic kidney disease. That is to say, the patient has the clinical manifestations of chronic renal failure, which requires strict control of diet, blood glucose and blood pressure and drug treatment. Clinical manifestations include obvious fatigue, nausea, loss of appetite, edema, chest tightness, palpitations (rapid heartbeat, often accompanied by panic), hyperkalemia and hyperlipidemia, anemia, and so on. It is recommended that patients with creatinine 260umol/L should consult the nephrology department of regular hospitals in time, and improve the relevant examinations under the guidance of doctors to clarify the cause, if it is caused by pathological factors, it should be actively treated to avoid delaying the condition.