You need to stop taking Norfloxacin for at least 5 days before drinking alcohol to avoid serious consequences. Norfloxacin belongs to the quinolone class of antibiotics, although unlike cephalosporin antibiotics, taking the drug after drinking alcohol may not cause disulfiram-like reactions. However, it may cause other side effects such as gastrointestinal reactions and skin allergies. In addition, these adverse reactions may be exacerbated if the drug is taken during alcohol consumption. It may also impair the body’s immunity, which is not conducive to recovery from the disease. As drinking alcohol also increases the burden on the liver, it affects the hepatic metabolism of quinolone antibiotics, the effective concentration of the drug and the anti-inflammatory effect of the drug. During the period of taking antibiotics, in addition to avoiding alcohol, but also avoid spicy, stimulating food. Drugs need to be used under the guidance of a professional physician, do not self-medicate.