Itching at the vaginal opening can be caused by the following reasons: 1. If the itching occurs in post-menopausal elderly women, the lack of estrogen causes the vulvar opening to atrophy, so you can consider applying estrogen creams, such as estradiol ointment, locally. 2. 3. If the itching is accompanied by abnormal discharge from the vagina, it is most likely due to trichomoniasis or mycotic vaginitis, it is best to have a pathogenic microbiological examination to clarify the nature of the inflammation and then choose the appropriate medication. You should try to wear loose, comfortable and breathable underwear and keep the area clean and dry.