The problem of pain in the ankle when sleeping up: 1, it may be because of excessive exercise during the day, or long-term fatigue exercise, or overworked with potential injuries, leading to sleep and wake up with symptoms of pain in the ankle. 2, it may also be because of poor local circulation, or varicose veins in the foot leading to pain symptoms. 3, or changes in the environmental temperature of the night time sleeping can also be Inadequate mineral content in the diet, such as calcium deficiency, can also lead to symptoms of ankle pain in bed. 5, there are certain chronic diseases, such as diabetes, gout, may lead to symptoms of ankle pain. 6, if combined with numbness, it may also be motor neuron disease, spinal radiculopathy, or peripheral neuropathy leading to ankle pain. 7, excessive emotional stress can also lead to pain in the ankle. 7, excessive emotional tension can also lead to pain in the ankle when sleeping. So we must pay attention to rest, reduce exercise, if there is no relief in the short term, we must go to the regular hospital in a timely manner, complete the necessary examinations, choose a reasonable treatment.