The main lipid-lowering drugs of the niacin class are niacin and acipimox, which are not often applied. Niacin belongs to the B vitamins and has a lipid-regulating effect when the dosage exceeds the dose used as a conventional vitamin. It inhibits lipolysis and reduces the synthesis and secretion of low-density cholesterol in the liver, mainly reducing triglycerides and mixed hyperlipidemia with mainly elevated triglycerides. The main side effects of niacin lipid-lowering drugs include facial flushing, itching, and also gastrointestinal symptoms. Therefore, they are not suitable for patients with gastrointestinal diseases, especially gastric ulcers. In addition, the application of diabetic patients will aggravate the itching of the skin, which is also not suitable for application. Its to start with a low dose and gradually increase to the ideal dose, once a night dosing, with relatively few side effects of Acipimox.