Most knee pain after squatting is caused by osteoarthritis of the knee joint or meniscus damage, which can be treated as follows: First, oral medication, which can be taken to nourish cartilage, such as glucosamine hydrochloride, glucosamine sulfate, or oral anti-inflammatory and pain medication, such as meloxicam, celecoxib, loxoprofen sodium tablets. Secondly, physical therapy, such as microwave physiotherapy or far-infrared therapy, can also be very effective in relieving knee pain. Third, intra-articular injection of drugs, intra-articular injection of sodium vitreous acid for the treatment of osteoarthritis of the knee joint, as well as the knee meniscus injury, have a very good effect. Fourth, proper rest should be taken to avoid excessive strain on the knee joint and to avoid getting cold, which can also relieve the pain of the knee.